Placenta-targeting LNP delivering VEGF mRNA for preeclampsia

A lipid nanoparticle (LNP) carrying VEGF mRNA and formulated to target the placenta could help treat preeclampsia by normalizing placental vasculature.

A high-throughput screen in pregnant mice of 98 DNA-barcoded LNPs identified placenta-targeting LNP formulations, and a subsequent screen for LNP-mediated delivery of a reporter mRNA identified one formulation that induced 183-fold greater placental reporter expression than the LNP used to deliver the approved siRNA drug Onpattro patisiran, with minimal liver expression and no fetal expression. ...