NUAK1 for gastric cancer chemoresistance

Inhibiting NUAK1, a kinase that stabilizes the Hedgehog pathway transcription factor GLI1, could help treat gastric cancer development and progression by decreasing oncogenic signaling and chemoresistance.

Bioinformatic analyses of public gastric cancer patient and mouse datasets identified NUAK1 as a top gene in all datasets that correlated with shorter overall survival and chemoresistance, and in patient samples, NUAK1 protein expression was higher in gastric cancer tumors than adjacent normal tissues. ...