CAR T cells targeting FGFR4 and B7-H3 for pediatric rhabdomyosarcoma

Bicistronic CAR T cells targeting both FGFR4 and B7-H3, two proteins overexpressed on the surface of rhabdomyosarcoma, could help treat the pediatric cancer more efficiently than single-protein targeted CAR T cells by decreasing tumor escape and increasing the chance of antigen recognition in heterogeneous tumors. 

RNA-sequencing showed FGFR4 and B7-H3 were increased in primary pediatric rhabdomyosarcoma patient tumors and a panel of human rhabdomyosarcoma cell lines compared with normal tissues...