Newly discovered hormone cholesin for hypercholesterolemia

Cholesin, a hormone secreted by the intestine in response to cholesterol absorption, could help treat hypercholesterolemia and atherosclerosis by suppressing liver cholesterol synthesis promoted by the transcription factor SREBP2, thus decreasing circulating cholesterol.  

In mice fed a 0.02% or 1.25% cholesterol diet after 16 hours of fasting, mass spectrometry identified a mouse homolog of the previously uncharacterized human protein C7orf50, dubbed cholesin, as the most increased protein in the plasma of mice fed high versus low cholesterol diet. ...