Targeting the ANXA2-TMPC interaction for gastric inflammation and cancer

Targeting the binding of the Streptococcus anginosus surface protein TMPC with the gastric epithelial surface protein ANXA2 could help treat gastric inflammation and prevent gastric cancer by blocking disruption of gastric barrier function and activation of tumorigenic MAPK signaling in epithelial cells.

S. anginosus was enriched in the stomachs of patients with gastric cancer or atrophic gastritis, who are at higher risk for developing gastric cancer, compared with patients who only had superficial gastritis, and in the gastric cancer patients, S. anginosus was enriched in tumors compared with matched healthy tissue. ...