Inhibiting PCKS9 for abdominal aortic aneurysm

Inhibiting cholesterol metabolism regulator PCSK9 could help treat abdominal aortic aneurysm by reducing low-density lipoprotein cholesterol (LDL-C).

A meta-analysis of 17 previously published GWAS studies that included more than 39,000 subjects with abdominal aortic aneurysm identified 141 independent risk variants, and subsequent gene expression analyses in relevant tissue types including smooth muscle and endothelial cells, network analysis, and Mendelian randomization modeling identified lipid metabolism pathways and PCSK9 as potential targets. ...