Expressing the lncRNA SNHG9 for obesity

Upregulating SNHG9, a host lncRNA expressed in intestinal cells and repressed by gut microbiota, could help treat obesity by binding to and blocking the endogenous SIRT1 inhibitor CCAR2, restoring SIRT1’s inhibition of the lipid metabolism regulator PPARγ.

Comparative transcriptomic analyses of the small intestine epithelia of germ-free mice and conventionally raised mice identified 42 differentially expressed lncRNAs including SNHG9, which was expressed at higher levels in germ-free mice. ...