Targeting the SUSD6-TMEM127 complex in cancer cells for anti-tumor immunity

Targeting the SUSD6-TMEM127 complex, which promotes ubiquitination and lysosomal degradation of MHC-I, could help treat cancer by increasing antigen presentation and antitumor immunity.

In human and mouse AML cell lines and a syngeneic AML mouse model, genome-wide CRISPR/Cas9 loss-of-function screens for negative regulators of MHC-I antigen presentation identified SUSD6 and TMEM127 as top hits...