Recombinant PF4 for cognitive impairment

Administration of recombinant PF4, a platelet-derived exerkine, could help treat age-related cognitive impairment by interacting with the chemokine receptor CXCR3 and promoting hippocampal neurogenesis.

PF4 protein levels were lower in the platelet-rich plasma of aged humans, as well as in the blood plasma and platelet fraction of aged mice, compared with samples from young individuals and mice, respectively. ...