Increasing CAND1 activity for nonalcoholic fatty liver disease

Promoting the activity of CAND1, a regulator of Cullin-RING E3 ubiquitin ligases, could help treat nonalcoholic fatty liver disease (NAFLD) by decreasing degradation of the fatty acid-oxidizing enzyme ACAA2.

Bioinformatic analysis of public data sets showed CAND1 mRNA expression was lower in liver biopsies of patients with NAFLD than healthy individuals, and mRNA expression and protein levels of CAND1 were lower in liver biopsies from an independent cohort of patients with NAFLD and mice fed a high-fat diet than from healthy individuals and mice, respectively. ...