Targeting UHRF1 for KRAS-driven lung cancer

Inhibiting UHRF1, an E3 ubiquitin ligase that promotes DNA methylation and DNA repair, could help treat KRAS-driven lung cancer by increasing expression of tumor suppressor genes.

In 3D cultures of primary mouse KRAS-mutant, p53-deficient lung cancer cells, shRNA knockdown screens of KRAS upstream modulators, downstream effectors and interaction partners identified UHRF1 as essential for spheroid growth. ...