Targeting SLC4A4 for pancreatic cancer

Inhibiting the bicarbonate transporter SLC4A4 could help treat pancreatic ductal adenocarcinoma (PDAC) by preventing immunosuppressive acidification of the tumor microenvironment.

In two cohorts of PDAC patients, single cell RNA sequencing analysis of candidate intratumoral pH modulators identified SLC4A4 as the most highly expressed bicarbonate transporter. ...