Increasing SOD3 activity for chemo-induced cognitive impairment

Increasing activity of the antioxidant enzyme SOD3 in the choroid plexus could help prevent methotrexate-induced cognitive impairment by decreasing oxidative stress in the CNS. SOD3 levels were lower in CSF samples from methotrexate-treated CNS lymphoma patients than in samples from healthy controls, and levels of metabolites that are hallmarks of oxidative stress were higher in the patient samples. ...