Neurocrine other research news

Scientists at Scripps Research Institute (La Jolla, Calif.) published in Science the ability of urocortin, a brain peptide, to suppress appetite in hungry rats without causing anxiety. The peptide is similar to CRF, which reduces appetite but brings with it other stress-reaction effects.

Rats deprived of food for 24 hours were tested for two hours following injection of urocortin into the ventricles of the brain. Food consumption in the rats was cut in a dose-dependent manner, and doses as low as 10 ng decreased food intake. In free-feeding rats, doses as low as 100 ng decreased food intake. ...