Quadramet data

Mean AUPC for both scales increased progressively during the first four weeks in the treated group, indicating pain relief, but did not increase in the placebo group. The differences between the treated and placebo groups were statistically significant at weeks 1 to 4 for the PDS scale, and at weeks 2 and 3 for the VAS scale.

Daily opioid analgesic use decreased over four weeks by 50 percent in the treated group, but increased by 80 percent in the placebo group. Differences between the two groups were significant at weeks 3 and 4. ...