Astex Therapeutics preclinical data

In in vitro models of lung and breast cancer, AT13887 suppressed expression of client proteins for >=7 days. AT13887 suppressed client protein expression for >=3 days in melanoma cells.

In in vivo models comparing AT13387 to 17-AAG and SNX-5422, AT13387 suppressed client protein levels for up to 96 hours and phosphorylated growth/survival signaling components. ...