ARTICLE | Discovery & Translation
Science Spotlight: Actionable pathways for cachexia and radioresistance in lung cancer
BioCentury’s translational roundup also includes a muscle-specific PROTAC platform and a dual tumor and TME-targeting CAR T therapy for glioblastoma
July 10, 2026 12:11 AM UTC
Two recent papers identify new levers for drug developers in lung cancer: one for systemic symptoms, and one for treatment resistance.
Researchers from New York University showed in Science that STK11-mutant lung tumors drive cancer-associated cachexia in mice by locally releasing the lipid-signaling molecule PGE2, which hijacks lung sensory neurons to suppress appetite and promote wasting...