ARTICLE | Discovery & Translation
Science Spotlight: Altos Labs’ cognition enhancer
Plus: A map of pain circuitry, a safer mu-opioid receptor agonist, and a small molecule that could prevent weigh rebound after GLP-1s
April 9, 2026 8:32 PM UTC
Longevity play Altos Labs Inc. and collaborators at Baylor College of Medicine identified persistent integrated stress response (ISR) activation as a potentially druggable driver of cognitive dysfunction.
In a mouse model of a human PPP1R15B mutation, which is tied to intellectual disability, the team showed that chronic ISR activation disrupts protein synthesis, synaptic plasticity, and long-term memory...