Science Spotlight: Trio of papers decodes endometrial biology

Three groups published articles focused on untangling endometrial biology, with a shared focus on regeneration/repair and capacity for implantation.

Peking University researchers identified defects in human endometrial tissues from polycystic ovary syndrome (PCOS) patients, showing that increased lactylation, the addition of lactate groups, to histones and ERα is a key indicator of impaired endometrial receptivity in the condition. In a Nature Communications report, the authors demonstrated that inhibiting histone lactylation downregulated ERα and estrogen-responsive genes, restored uterine receptivity, and improved implantation rate in PCOS mice...