Even endpoint hits don’t spare shares in three weight-loss updates

Fractyl Health was the biggest mover on clinical data for the week of Jan. 29 to Feb. 4, shedding 68% Tuesday after its GI resurfacing procedure did not live up to expectations in the weight loss maintence setting after GLP-1 treatment.

Patients administered Revita from Fractyl Health Inc. (NASDAQ:GUTS), an endoscopic procedure intended to restore healthy nutrient sensing in the duodenal mucosal, experienced 4.5% weight regain vs. 7.5% in the sham arm at six months, a numerical trend that did not reach significance (p=0.07, one-sided). ...