BioCentury
ARTICLE | Product Development

Roche’s GLP-1/GIP entering late-stage with competitive efficacy

Early results suggest CT-388 may outperform Wegovy/Zepbound, in league with Lilly’s triple combo

January 29, 2026 1:52 AM UTC

Among the bright spots in the clinic this week were Phase II results suggesting Roche’s dual GLP-1/GIP agonist has competitive weight loss efficacy.

In the CT388-103 study, weekly injections of 24 mg CT-388 led to placebo-adjusted weight loss of 22.5% at 48 weeks in 469 people with obesity, without reaching an efficacy plateau. ...