Science Spotlight: Thwarting melanoma immune evasion

Tel Aviv University researchers and collaborators revealed that blocking release of melanosomes, pigment-containing organelles that store and transport melanin, from melanoma cells can slow tumor growth. 

The Cell paper authors found that melanoma cells load classical human leukocyte antigen (HLA)–peptide complexes into secreted melanosomes, which display these complexes on their surface and compete with tumor cells for CD8⁺ T cell engagement...