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ARTICLE | Deals

Neurocrine taps China biotech for NLRP3 programs: Deals Report

Plus: Roche/Manifold, 4D/Otsuka, the latest on Novo’s bid to upend the planned Pfizer/Metsera deal, and more

November 4, 2025 1:02 AM UTC

Neurocrine will add a portfolio of NLRP3 programs via a deal with China-based TransThera, adding the closely watched neuroinflammatory target to its pipeline.

TransThera Sciences (Nanjing) Inc. did not disclose the size of the deal’s upfront payment in a regulatory filing, but said the agreement’s total value could rise to $881.5 million, contingent on milestone payments. Its deal with Neurocrine Biosciences Inc. (NASDAQ:NBIX) excludes mainland China, Hong Kong, Macau and Taiwan, but does encompass a research collaboration between the companies...