BioCentury
ARTICLE | Deals

Roche-Orionis, Vantai-Blueprint partner on molecular glues: Deals Report

Biogen-City to develop RNAi-based CNS therapies. Juri licenses T cell engager from Epimab. Plus: Pfizer-3SBio, Sanofi-Vigil and Altos-Dorian

May 28, 2025 12:55 AM UTC

Pfizer Inc. (NYSE:PFE) paying $1.25 billion to license ex-China rights to a PD-1 x VEGF therapy from 3SBio Inc. (HKEX:1530) remained the biggest deal of the past week, but a handful of other transactions shared the spotlight — including two molecular glue partnerships.

In a May 21 deal worth $105 million up front, molecular glue company Orionis Biosciences Inc. announced a second multiyear collaboration with the Genentech unit of Roche (SIX:ROG; OTCQB:RHHBY). Their first partnership centered on targeted protein degraders for cancer and neurology, while this second one focuses on non-degrading molecular glues for cancer...