Isomab: Rebalancing VEGF-A isoforms to promote blood vessel formation

Isomab is developing an antibody that hits only the anti-angiogenic isoform of VEGF to ‘remove the brake’ on blood vessel formation.

The blood vessel stimulating effects of vascular endothelial growth factor (VEGF) were discovered in 1989. Since then, scientists have tested recombinant versions of VEGF and molecules that stimulate VEGF signaling as mechanisms to induce angiogenesis in patients, but none of the methods have worked. ...