BioCentury
ARTICLE | Data Byte

New AMD data showcase the promise and high bar for vectorized biologics

Two gene therapies reduced the need for VEGF injections, but just the suggestion of imperfect safety sent shares of one company tumbling 

July 18, 2024 1:39 AM UTC

Interim results from Phase II trials of two wet AMD gene therapies encoding versions of aflibercept further build the case for a future in which one-time treatments with vectorized biologics supplant chronic injections of established products. Investor reaction, however, showed getting from here to there may be challenging, as even a hint of a safety issue can sink shares.

On Wednesday, 4D Molecular Therapeutics Inc. (NASDAQ:FDMT) and Adverum Biotechnologies Inc. (NASDAQ:ADVM) each presented Phase II data at the American Society of Retina Specialists Annual Scientific Meeting...