Science spotlight: Tumors siphon taurine from T cells, and Revolution’s RAS (ON) inhibitors

A study in Cell showed tumor up-regulation of the taurine transporter SLC6A6 drives CD8⁺ T cell exhaustion by depriving them of the metabolite, which protects the T cells from ER stress.

Researchers at Fourth Military Medical University showed that high SLC6A6 expression in patient tumors was associated with aggressiveness and poor outcomes in multiple cancers. The team identified a mechanism by which chemotherapy induces SLC6A6 overexpression in gastric cancer, downstream of the transcription factor SP1...