Blood signature of organ aging; plus updates from Roche, Feldan, Rezo
BioCentury’s roundup of translational innovations
A team led by Teal Omics Inc. co-founder Tony Wyss-Coray at Stanford University described a machine learning method in Nature to estimate the age of organs using human blood plasma proteins originating in specific organs. The authors found that people with accelerated heart aging, as assessed by the method, have a 250% increased heart failure risk, while accelerated brain and vascular aging predicted Alzheimer’s disease progression as well as the current best blood-based biomarker for Alzheimer’s.
Roche (SIX:ROG; OTCQX:RHHBY), WuXi AppTec Co. Ltd. (Shanghai:603259; HKEX:2359) and Axxam S.p.A. described in Cell Chemical Biology a selective HCN1 inhibitor that enhanced working memory in rats without the cardiovascular effects observed with non-selective HCN inhibitors that also bind cardiac-expressed HCN isoforms 2/3/4...