Myricx: ADCs with a lipidation inhibitor payload

Myricx is pioneering a post-translational modification inhibitor of myristoylation as the payload for antibody-drug conjugates.

Myristoylation is a lipid modification involving the addition of myristic acid, a 14-carbon fatty acid, to the N-terminus of proteins, catalyzed by the enzymes NMT1 and NMT2. The modification dictates signal transduction, protein stability and localization of proteins to membranes. About 150 human proteins are myristoylated...