ARTICLE | Discovery & Translation

Mini Cas protein iterations; plus Moderna’s Lassa virus vaccine and more

BioCentury’s roundup of translational innovations

September 15, 2023 10:24 PM UTC

Two groups published iterations of miniature Cas proteins.

A team led by Zhaowei Wu and Quanjiang Ji at ShanghaiTech University reported in Nature Chemical Biology a miniature Cas12f nuclease engineered to recognize C-rich protospacer adjacent motifs (PAMs) for DNA targeting, which widens the target scope since most characterized Cas12f nucleases recognize T-rich PAMs. The authors filed a patent related to the work...