ARTICLE | Discovery & Translation

Improved transgene insertion; plus Synlogic’s autoimmune probiotic and more

BioCentury’s roundup of translational innovations

August 17, 2023 11:50 PM UTC

Two groups showed the DNA-PK inhibitor AZD7648 enhanced targeted transgene integration, a finding that could increase the therapeutic efficacy and safety of genome editors.

A team led by Matthew Porteus at Stanford University reported in Nature Biotechnology that AZD7648 increased homology-directed repair up to 50-fold and concomitantly decreased unwanted genomic insertions/deletions (INDELs) in vitro...