ARTICLE | Discovery & Translation

Keeping up with the protein designers

As machine learning methods leapfrog each other, protein design companies must navigate the benefits and challenges of an ever-evolving toolbox

May 11, 2023 6:32 PM UTC

The rapid evolution of de novo protein design methods means companies must remain poised to “bake-off” new approaches as they come out, while weighing the value of keeping innovations proprietary versus staying as current and compatible as possible by being open.

The past few years have seen big steps forward in several types of computational technologies related to protein design, including those that generate desired scaffolds, those that identify amino acid sequences capable of forming those scaffolds, and those that predict the final conformations of amino acid sequences (see Figure)...