Ubiquitin-regulation for tauopathies; plus Regeneron’s IL2RG mAb for T cell-driven disease and more

A Baylor College of Medicine team led by  Cajal Neuroscience Inc. co-founder Huda Yahya Zoghbi identified three ubiquitin regulators — USP7, RNF130 and RNF149 — in a cross-species screen whose knockdown decreased tau accumulation and cognitive deficits in a mouse model of tauopathy by relieving suppression of the E3 ubiquitin ligase STUB1, which promotes tau degradation. Results were published in Neuron. Cajal was founded in 2020 to integrate brain mapping techniques with genetics to discover neurodegeneration targets.

Peking University researchers and colleagues, including Spot Biosystems Ltd employees, induced prolonged collagen synthesis and reduced wrinkle formation in the dermal tissue of mice with photo-aged skin via intradermal delivery of extracellular vesicles carrying mRNA encoding COL1A1. The vesicles, described in Nature Biomedical Engineering, were produced via nanoporation of human dermal fibroblasts...