Valuing ADC licensing deals
As data roll in for clinical ADCs licensed since 2020, upfront payments for preclinical deals show signs of growth
AZ and Daiichi’s datopotamab deruxtecan data marks the latest readout of the value emerging from ADC licensing and partnering deals made since 2020. A pair of recent preclinical deals suggest the modality’s forward momentum is buoying upfront payments for next-generation ADC cancer therapies.
The ADC space has seen a series of high-profile company acquisitions and licensing deals, including the 2019 partnership between AstraZeneca plc (LSE:AZN; NASDAQ:AZN) and Daiichi Sankyo Co. Ltd. (Tokyo:4568) for the now standard-setting Enhertu fam-trastuzumab deruxtecan-nxki, then in Phase III testing, which brought Daiichi $1.4 billion up front and eligibility for $5.5 billion in milestones...
BCIQ Target Profiles
Epidermal growth factor receptor 2 (HER2) (EGFR2) (ErbB2) (neu)
Folate receptor 1 (FOLR1) (FR-alpha) (FOLR)
Receptor tyrosine kinase-like orphan receptor 1 (ROR1)
Solute carrier family 39 zinc transporter member 6 (SLC39A6) (LIV-1) (ZIP6)
Tumor-associated calcium signal transducer 2 (TROP2) (TACSTD2) (EGP-1)