ARTICLE | Emerging Company Profile
Cartesian expanding therapeutic window, disease settings for CAR T
CAR T therapy for myasthenia gravis shows strong efficacy, though questions remain about durability
May 13, 2022 9:58 PM UTC
Cartesian’s use of mRNA to drive expression of CARs in cell therapies may reduce the amplifying effect of DNA-based CAR therapies and associated toxicity, making its treatments more amenable to indications beyond cancer.
Launched in 2016, Cartesian Therapeutics Inc. is using mRNA, rather than lentiviral or CRISPR-based DNA engineering methods, to express the chimeric antigen receptor (CAR) in its cell therapies...
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