BioCentury
ARTICLE | Data Byte

Moderna’s mRNA vaccine adds to a short IDO pipeline

Moderna’s candidate aims to stimulate T cell responses to IDO1 and PD-L1

February 19, 2022 2:32 AM UTC

Moderna is betting its mRNA vaccine take on IDO and checkpoint inhibition will overcome the hurdles that befell Incyte’s small molecule inhibitor by relying on immune killing instead of biochemical inhibition.

The program is one of seven against the metabolic regulator, five of which are in clinical trials, according to BioCentury’s BCIQ database...