The TAC universe grows beyond PROTACs
Inducing autophagy is becoming a popular strategy as targeting chimeras extend beyond protein degradation
On the heels of success using the proteasome to degrade protein targets, a growing crop of companies are turning to autophagy to destroy a broader array of disease-driving substrates.
The TAC (therapeutic targeting chimera) space took off with modular compounds known as proteolysis targeting chimeras (PROTACs), which ubiquitinate targets and send them to the proteasome for degradation...
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