WHO meeting highlights correlates of protection questions for next-gen COVID vaccines

A Wednesday meeting hosted by WHO seeking to clarify the next steps in defining correlates of protection for next-generation COVID-19 vaccines underscored the need to determine if prediction thresholds can be harmonized across modalities and whether serum markers are valid predictors of efficacy for vaccines aiming for strong mucosal immunity.

Establishing correlates of protection is a priority for next-generation vaccine research because vaccines require massive studies to determine efficacy directly. ...