BioCentury
ARTICLE | Product Development

Self-amplifying may be the next frontier in RNA therapies

Self-amplifying RNA brings a differentiated immune profile, enables lower doses

March 19, 2021 7:29 PM UTC

With the success of mRNA vaccines for COVID-19 solidifying the technology as a vaccine modality that’s here to stay, the conversation has turned to where mRNA will make its mark next and what’s needed in a second generation of the technology.  

Self-amplifying RNA is increasingly on companies’ radars as a path to vaccines for both infectious diseases and cancer given their ability to evoke strong cytotoxic T cell responses and enable lower, longer-lasting doses than “conventional” mRNA. ...



Access The Full Article