Distillery Therapeutics


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<h1 class="text title distillery_title" doc-editable="text" data-component-id="doc-1ef7l992d0">Targeting histone trimethylation to treat Alzheimer&#x2019;s</h1><div class="byline ng-tns-c17-4 ng-star-inserted" data-component-id="doc-1ef7l9he70">
    <span class="ng-tns-c17-4" doc-editable="text">By Claire Quang, Staff Writer</span>
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

University at Buffalo

DISEASE CATEGORY: NeurologyINDICATION: Alzheimer&#x2019;s disease......

Neurology

Alzheimer's disease (AD)

WD repeat domain 5 (WDR5)

Myeloid-lymphoid or mixed-lineage leukemia protein (MLL1) (MLL) (HRX) (KMT2A)

Serum/glucocorticoid regulated kinase 1 (SGK1)

Targeting histone trimethylation to treat Alzheimer’s

DISEASE CATEGORY: Neurology<br/>INDICATION: Alzheimer&#x2019;s disease Inhibiting WDR5, a core subunit of the MLL family of&#xA0;histone methyltransferases, or its downstream target SGK1 could treat

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