Distillery Therapeutics


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<h1 class="text title distillery_title" doc-editable="text" data-component-id="doc-1ef7l992d0">SIRT5 overexpression could rescue mitochondrial disease induced by SUCLA2 mutations</h1><div class="byline ng-tns-c17-4 ng-star-inserted" data-component-id="doc-1ef7l9he70">
    <span class="ng-tns-c17-4" doc-editable="text">By Claire Quang, Staff Writer</span>
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

Gladstone Institutes

University of California San Francisco

University of Helsinki

Buck Institute for Research on Aging

DISEASE CATEGORY: Endocrine/metabolicINDICATION: Mitochondrial disease......

Endocrine/Metabolic

Mitochondrial disease

Succinate-CoA ligase ADP-forming beta subunit (SUCLA2)

Sirtuin 5 (SIRT5)

SIRT5 overexpression could rescue mitochondrial disease induced by SUCLA2 mutations

DISEASE CATEGORY: Endocrine/metabolic<br/>INDICATION: Mitochondrial disease Promoting the expression of the desuccinylase SIRT5 could treat a hereditary mitochondrial encephalomyopathy caused by

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