How COVID-19 challenge trials will be shaped by emerging data 

The CRO behind the first COVID-19 human challenge trials plans to adapt its inclusion criteria and endpoints as the risks of SARS-CoV-2 infection become better understood.

Critics worry that lingering uncertainty about the virus’ effects means human challenge trials are still too dangerous, and that the exclusion criteria used to reduce the studies’ safety risks will limit the utility of their results. ...