Cell Therapeutics preclinical data

Data from cell cultures showed that the synthetic small molecule has an immunosuppressive action distinct from that of cyclosporin and FK-506.

The compound blocked T cell activation by interleukin-2 at low concentrations, but did not induce any toxicities in a variety of cell types at concentrations a thousand- to ten-thousandfold higher. The 50-percent inhibitory concentration that stopped IL-2's activation was in the range of 200-850 nanomolar. ...