CytoTherapeutics data

CTII's encapsulated cell implant delivered biologically significant quantities of recombinant nerve growth factor to the brains of rats, according to research reported in the July Experimental Neurology. Delivery of NGF to the lateral ventricle of fimbria-fornix of the brain prevented lesion-induced reduction of neuronal cell activity in six rats implanted with rat fibroblasts genetically modified to produce NGF. Each capsule produced about 10 ng of NGF per day. Six rats implanted with capsules containing fibroblasts that didn't produce NGF showed reduced neuronal cell activity. ...