Corvas International other research news

CVAS researchers and university colleagues reported in the Proceedings of the National Academy of Sciences on the cloning and anticoagulant properties of a new family of small proteins. The NAPs (nematode anti-coagulant proteins) were isolated from the hookworm Ancylostoma caninum.

NAP-5 and NAP-6 directly inhibit the blood clotting enzyme Factor Xa. A third family member, NAPc2, inhibits the enzymatic complex of Factor VIIa and tissue factor (TF) by a unique mechanism of action: the Factor VIIa/TF complex initiates the coagulation cascade, rendering it attractive for antithrombotic drug development, CVAS said. ...