DNA amplification and analysis of urine for diagnostic purposes data

A method of analyzing microsatellite DNA markers in urine proved to be 95 percent accurate in detecting primary bladder cancer, according to a study published in Science. The study was conducted by researchers at Johns Hopkins Medical School; the technology has been licensed to ONC.

In a blinded trial, urine samples were taken from 25 patients who had suspicious bladder lesions as identified by cytoscopy. DNA from lymphocyte cells in these samples were analyzed for simple repeat sequences, or microsatellites, and mistakes in replication, such as additions or deletions. ...