Ariad other research news

ARIA published the precise molecular structure of the domains of the T cell receptor that bind ZAP-70, a member of the protein tyrosine kinase class of cell signaling proteins.

As detailed in Nature, X-ray crystal structure of the receptor, bound to ZAP-70, shows binding at two contact sites, the SH2 domains. The two domains together form a docking site, instead of serving as independent binding sites as thought previously. ...