Tissue plasminogen activator data

The German company's tPA was tested in the European Cooperative Acute Stroke Study, in 620 patients, with some indication of better functional outcome. However, the gain was offset by more frequent bleeding in the brain.

As reported in the Journal of the American Medical Association, there was no difference in two functional outcome rating scales in an intent-to-treat analysis. There was, however, a significant difference in one of two measures in a subgroup defined as the target population for the trial. ...