Canji Inc. preclinical data

The company also reported at the Gene Therapy of Cancer meeting in San Diego that p56, a shortened form of the Rb tumor suppressor gene, is a more potent inhibitor of cell cycle progression than is full-length Rb.

Adenoviruses bearing either the full-length or shortened gene were able to inhibit growth of Rb-negative tumor cell lines, but inhibition occurred at lower levels of gene expression for the shorter gene. ...