Isis preclinical data

ISIP (Carlsbad, Calif.) presented animal data on its antisense inhibitor of ICAM-1, showing delay in rejection of transplanted hearts.

As reported at the American Society of Transplant Physicians in Chicago, untreated mice reject heart allografts at a mean of 7.7 days, while mice given the agent almost doubled the survival time of the transplant (p<0.01). ...